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Proceedings of the National Academy of Sciences of the United States of America

Five years after treatment or remission is used as a conservative review window rather than a proven biological cutoff

Some common signs of low vitamin B12 include: Tiredness and fatigue Glossitis (sore and red tongue) Paler skin than usual Unbalanced mood Pins and needles Difficulty concentrating and brain fog Signs and symptoms can vary from person to person and are often not exclusive to vitamin B12 deficiency

Digestive issues: Loss of appetite, weight loss, constipation, or diarrhea

Some users alternate by day