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Our unpublished calculations, using a structure similar to the models previously employed [2] for studying B12-dependent processes with the CASSCF electronic structure method, which involves 13 electrons and 13 orbitals in their active zone, reveal that the bio-inactive cofactors, aquacobalamin and cyanocobalamin, cannot directly participate in vitamin B12-dependent reactions

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The H 1 R protein is coupled to a G q -type G-protein