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(See Appendices A and B for the meaning of these classifications.) Surgery Surgery is the mainstay of treatment, with a safety margin depending on Breslow thickness

389 The interaction between GLP-1 and its receptor GLP-1R initiates the AMPK signaling cascade within skeletal muscle tissue

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Safety and efficacy of tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan (SURPASS J-combo): a multicentre, randomised, open-label, parallel-group, phase 3 trial