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10.1016/j.regpep.2009.05.008 3 BarisicI.BalenovicD.KlicekR.RadicB.NikitovicB.DrmicD.et al (2013)

GLP-1 is rapidly degraded with a half-life of less than two minutes by dipeptidyl peptidase-4 (DPP-4) in humans [53]

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Maximum benefits typically develop over 2-4 weeks as B12 levels normalize throughout your body