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Finally, inhibition of the endoplasmic reticulum stress kinase prior to TMAO treatment blocked all effects of this metabolite on VIC phenotype

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Given the critical regulatory roles of lncRNAs in cancer progression and the distinct membrane-disrupting and cytotoxic mechanisms of Polybia-MP1, it is plausible that the interaction of this peptide with cancer cells could influence the expression of key oncogenic or tumor-suppressive lncRNAs

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Doctors can sometimes prescribe medications off-label, meaning outside the FDA-approved uses listed on the label