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This is particularly true for people with hemophilic arthropathy (joint damage), which can make movement and exercise more difficult
Respiratory suppression (although this is typically associated with much higher doses of phenobarbital than 20 mg/kg)
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In contrast, SGLT2i have metabolic effects on the myocardial and renal cells that mimic energy starvation, simulating autophagy and other changes that counteract the progression of HF
J Steroid Biochem Mol Biol 165 , 101108, (2017)
Very large individuals (over 100kg) might tolerate the higher end
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