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Potent body weight loss and efficacy in a NASH animal model by a novel long-acting GLP-1/Glucagon/GIP triple-agonist (HM15211)
Foundational, clean, and essential to oxidative pathway research
Next, to ask whether the effect of DIV-1 on germline proliferation is specific to GLP-1/Notch signaling, we depleted the expression of div-1 by RNAi in gld-3(q730) nos-3(q650) mutants with synthetic germline tumors
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When combined with 5-Amino-1MQ, which inhibits NNMT (nicotinamide N-methyltransferase) to preserve NAD+ pools, the two compounds target overlapping but mechanistically distinct pathways
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