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DSIP's relatively short in vitro stability due to enzymatic degradation distinguishes it from more stabilized peptide analogs, making it a useful model for studying peptide metabolism and signaling kinetics

Zepbound, a GLP-1 receptor agonist, is also a mimetic of a hormone called glucose-dependent insulinotropic polypeptide (GIP)

reducing the risk of hyperglycemia

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The tradeoff is that semaglutide generally produces slightly less weight loss than tirzepatide in clinical comparisons, as tirzepatide is a dual GIP/GLP-1 agonist while semaglutide only targets GLP-1