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LivPGC-1 mice displayed a significative increase of Superoxide dismutase 2 (Sod2), Thioredoxin 2 (Txn2) and Peroxiredoxin 3 (Prdx3) mRNA levels, that was still preserved after APAP injection

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For example, multiple acyl-CoA dehydrogenase deficiency (MADD), caused by mutations in genes that impair the activity of enzymes involved in the transfer of electrons from acyl-CoA to coenzyme Q 10 , is usually responsive to riboflavin monotherapy yet patients with low coenzyme Q 10 concentrations might also benefit from co-supplementation with coenzyme Q 10 and riboflavin (27)

There several potential targets within the pathway from fructose to active RAGE that could be considered for modulating the fructose-initiated AGE-RAGE axis (Figure 5, red arrows 17)

DOI: Publisher Name: Humana Press, Cham Print ISBN: 978-3-319-19095-2 Online ISBN: 978-3-319-19096-9 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

10.1158/0008-5472.CAN-05-1925 33 Elrod J