Pen / Pre-mixed Reference Format Pre-mixed vial Concentration 100 mg/mL Dose example 50 mg Volume per dose 0.50 mL (50 units) Format Pre-mixed vial Concentration 100 mg/mL Dose example 100 mg Volume per dose 1.00 mL (100 units) Format Pre-mixed vial (high-conc.) Concentration 200 mg/mL Dose example 100 mg Volume per dose 0.50 mL (50 units) Format Pen device Concentration Set per device Dose example Click-set per dose Volume per dose Per device label Always verify label concentration and pharmacy beyond-use dating
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At 2,500 mcg/mL, that dose is 0.1 mL, which equals 10 units on a U-100 syringe
doi:10.1016/j.bcp.2018.05.003 Neelakantan H, Brightwell CR, Graber TG, et al
However, markedly elevated levels without supplementation may warrant GP review to exclude underlying conditions such as haematological disorders, liver disease, or renal impairment