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Chen WY et al

Chronic inflammation contributes to everything from joint pain to heart disease

It's a delicate, sophisticated biological process

To be eligible, participants had to be between 25 and 40 years of age, to be healthy as per site physician medical assessment, to be working for 812 h per day, and to have a body mass index (BMI) between 18.5 and 27.5 kg/m 2

Metformin is biotransformed to a small extent and is transported unbound to proteins as an organic cation

Given the multifactorial nature of HF, single-target interventions are unlikely to suffice, and multimodal strategies combining pharmacological agents, exercise, dietary approaches, and nutraceuticals may offer synergistic effects