2021 Jan 7;16(1):1
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TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation
Free Radic Biol Medic 122:420 Ding L, Charles MT, Carissea O, Tsao R, Dube C, Khanizadeh S (2011) Changes in ascorbateglutathione pathway enzymes in response to Mycosphaerella fragariae infection in selected strawberry genotypes
Like cisplatin, it contains two chloride ligands, which are released within the cellular environment and interact with DNA to form intra- and interstrand cross-links.3 These DNA adducts trigger multiple cellular responses, including DNA damage recognition and repair, cell cycle arrest, and activation of apoptotic signaling pathways, ultimately inhibiting cell proliferation.4 Ovarian cancer remains one of the leading causes of mortality among gynecological malignancies, with epithelial ovarian carcinoma accounting for more than 90% of all cases.5 The current standard therapy involves primary cytoreductive surgery followed by platinum-based combination chemotherapy administered as soon as possible after surgery.6 However, a major limitation of these treatments is the dose-dependent toxicity associated with platinum compounds, which can result in significant off-target tissue injury.7 It is well established that Reactive Oxygen Species (ROS) generated during the metabolism of platinum-based agents contribute to this toxicity, particularly in the reproductive system
Blood tests may be arranged to check testosterone levels (repeated in the morning), glucose, lipids, thyroid function, and sometimes LH/FSH and prolactin
