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Retinol is an over-the-counter vitamin-A derivative that the skin must convert into retinoic acid (the active form) over multiple steps

It also plays a role in growth hormone replacement therapy, aiming to restore GH release to optimal levels

However, their therapeutic potential is limited by rapid metabolism and poor bioavailability

Rumack BH, Bateman DN

its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin