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Inflammation-associated cytokine signaling (e.g., IL-1, TNF-) can suppress the GnRH drive by interfering with the kisspeptin-GnRH neuronal network, thereby disrupting LH/FSH secretion (particularly destroying the pulsatile rhythm of LH) (133, 134)

First, leptin increases the transcription of the Bdnf gene in proestrus but not diestrus, with specific changes in expression of exons I, II, III, and VI

It modulates gene expression across a range of pathways simultaneously

Waiting for a menopause diagnosis before addressing it means waiting through the years when intervention is most effective

Peptides are little proteins consisting of multiple amino acids that make up the tissue, muscles, organs, skin, and body hair