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Tirzepatide activates both GLP-1 and GIP receptors simultaneously, producing a synergistic effect that reduces appetite and increases fullness more powerfully than single-receptor agonists

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Conclusions Together, once-weekly 2.4 mg semaglutide reduced all-cause mortality by 19%, CV deaths by 15%, and non-CV deaths by 23% among non-diabetic obese or overweight patients with CV disease

6, Springer Science+Business Media, May 2022, pp