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24,25 Leptin responsive neurons in the ARC include those containing the agouti-related peptide (AgRP) and orexigenic peptides neuropeptide Y (NPY), and those containing the anorexigenic peptides -melanocyte-stimulating hormone (-MSH) and cocaine and amphetamine-regulated transcript (CART)

Examples may include: Nausea: This is the most common side effect

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Its action on these three receptors suggests a complementary mechanism where glucagon-induced gluconeogenesis is inhibited by GLP-1/GIP, and glucagons enhancement of energy expenditure is augmented by the appetite-suppressing effects of GLP-1/GIP, thereby promoting weight loss [112]

During gestation, fetus expresses gamma globin, which makes up fetal Hb

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