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The results revealed that there were no significant changes in mean pinprick sensation observed from baseline to 30 minutes

In DPPOS year 9, vitamin B 12 deficiency rates were 4.4%, 5.9%, and 4.9% for GG, AG and AA genotype groups in the placebo arm, vs 5.7%, 6.6%, and 18.7% in those respective genotype groups in the metformin arm (ESM Table 9)

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For reasons of health and safety, the acquisition of ampoule openers may be necessary