Pharmaceuticals (Basel) 2022, 15(6)
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(FDA approvals of Wegovy for cardiovascular disease and Zepbound for sleep apnea occurred in 2024 and therefore these uses are likely not reflected in Part D data through 2024.) More than half of gross spending in 2024 was on semaglutide products (Ozempic, 47%
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Functionally, zone 1 hepatocytes are specialized for oxidative liver functions such as gluconeogenesis, b-oxidation of fatty acids, and cholesterol synthesis, while zone 3 cells are more important for glycolysis, lipogenesis, and cytochrome P-450based drug detoxification