That said, heres a conservative framework: Usually given 13 months, followed by a break
It is an option when oral B12 is poorly absorbed or insufficient
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Plasma Fibroblast Growth Factor 21 Is Associated With Severity of Nonalcoholic Steatohepatitis in Patients With Obesity and Type 2 Diabetes
Neuropsychopharmacology 31 , 778786 (2006)
Notably, in older individuals with the increased lipid turnover rate, suggesting that myelin becomes more susceptible to damage with aging (Ando et al., 2003)