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However, due to the complexity of the composition of the microbiome and its effect on the organism, future research needs to gain a deeper understanding of the esophageal and intestinal microbiome and their metabolites in GERD through basic research to understand how the microbiome and their metabolites influence the occurrence of GERD, and also in the pathogenesis of GERD, abnormalities in digestive tract dynamics are gradually being emphasized by researchers

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The absence of published safety concerns in animal studies does not establish an acceptable human risk profile

While trial averages provide useful benchmarks, individual results vary based on starting weight, metabolic factors, diet quality, and physical activity levels

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