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The LNP-mRNA therapy eliminated pulmonary fibrosis and restored the ECM environment, which increased the plasticity of AT2 and Pclaf + cells to rescue AT1 cell population (Fig

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Emerging human data, including small pilot studies showing good tolerability (e.g., intravenous infusions up to 20 mg with no adverse effects) and subjective improvements in conditions like chronic knee pain, further support its promise

This pathway is of particular interest in aging or repeatedly injured tendons where receptor sensitivity may be reduced