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Simulation of the oral bioavailability calculation process [4] In vivo methods to obtain F a F g Values In vivo methods to obtain F a g Studies have shown that F a F g is more suitable than F for evaluating the intestinal absorption of compounds, as it clearly indicates whether low oral bioavailability is caused by low intestinal permeability or high hepatic metabolism, facilitating the optimization of bioavailability in later stages (Table 1)

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Not cleaning rubber stoppers with alcohol before each use invites contamination