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Diabetologists say that most GLP-1 patients regain lost weight within a year after they stop taking the drug, which encourages dependence

Huang and London, 2016)

Our team at Centra Internal Medicine will guide you through every step of semaglutide therapy

As mentioned, GLP-1s may affect areas of the brain that underlie reward and motivated behavior

It promotes inflammation by disrupting the intestinal epithelial barrier, inducing pro-inflammatory cytokines, such as IL-1, IL-6, IL-17F, and TNF-, and activating signaling pathways including NF-B and the IL-17F axis (Zheng et al., 2025)

Bull World Health Organ 45:243253 Ethics declarations Ethical approval Not applicable