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Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy

PCR data showed that 200 M H 2 O 2 treatment upregulated IL-1, MMP13, Collagen-X, Caspase3, and Caspase9 at mRNA level in chondrocytes, while metformin significantly attenuated these H 2 O 2 exposure induced increases (Fig

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It is possible that GLP-1R agonists reduce cocaine seeking, in part, by increasing GABA release from presynaptic terminals in the VTA, effects consistent with the post-synaptic mechanism revealed in the current study