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Further, reduced motivation to obtain sucrose induced by exendin-4 reversed by GLP-1 receptor antagonism, suggesting the effect may be specifically reward-related (Dickson et al

Starting at 1 mg rather than the standard 0.25 mg is off-label but widely practiced for patients transitioning from high-dose GLP-1 therapy

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The study, which hasnt been peer-reviewed, tracked nearly 150,000 people taking GLP-1 drugs, including the blockbuster weight-loss medications Ozempic and Wegovy

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Knowing that metformin has impact on these parameters, it is possible that metformin maxed out with the observations for those two groups of outcomes