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doi: 10.3389/fimmu.2026.1773284 Received 22 December 2025 Revised 13 February 2026 Accepted 05 March 2026 Published 26 March 2026 Volume 17 - 2026 Edited by Sudhir Gupta, University of California, Irvine, United States Reviewed by Charlotte Slade, The University of Melbourne, Australia Anupriya Kaur, Post Graduate Institute of Medical Education and Research (PGIMER), India Updates Copyright 2026 Jans, Al, Bouman, Geelen, Kleefstra and Placek

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Maresch CC, Stute DC, Alves MG, Oliveira PF, de Kretser DM, Linn T

Confirmatory diagnostic studies should be performed prior to initiating therapy, if possible, and the patient should be followed with appropriate studies to demonstrate hematologic improvement (Hgb, hematocrit, RBC, reticulocyte count)