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Other participants in the TCA cycle are also more active in KRAS-mutant tumors, particularly in pancreatic ductal adenocarcinoma (PDAC), where the increased expression of GOT1/2 supports glutamine metabolism while producing NADPH to maintain REDOX balance [50]

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Cardiovascular outcome trials have indicated that GLP-1RAs can decrease the primary composite outcome of first-time major adverse cardiovascular events (MACE) among diabetes patients (20)

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Clinical trials showed 24.2% average weight loss at 48 weeks using the 12mg dose