The goal is the minimum effective dose, not the maximum tolerable dose
Shorb knew that the same liver extract was used to treat pernicious anemia (her father-in-law had died from the disease), and concluded that LLD could be developed as an assay method to identify the active compound
In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 g vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)
The real issue often lies deeper, at the cellular level
It is actually one of the symptoms of pernicious anemia that people may notice first and is a symptom that may respond quickly to B12 supplementation
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