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It is particularly relevant for patients with widespread plaques or psoriatic arthritis where systemic immune modulation is desirable

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Recognition of client proteins by the proteasome

Gantz I, Erondu N, Mallick M, Musser B, Krishna R, Tanaka WK, et al

Common symptoms include fatigue, blurred vision, optic neuritis, limb weakness or sensory disturbances, dizziness, balance problems, cognitive impairment, and bladder dysfunction (53)

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