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Causality assessment of adverse reactions to drugs-I

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17(3): 293-303 JAMA 2023

The principal mechanism driving AOPPs generation involves the activated myeloperoxidase-H 2 O 2 -chloride system in neutrophils, with myeloperoxidase serving as the sole enzyme capable of generating chlorinated oxidants (Figure 2) ( FIGURE 2 As markers of oxygen-mediated protein damage, AOPPs have been identified as indicators of oxidative protein damage and proinflammatory mediators ( 3.2.2 Advanced glycation end- products Advanced glycation end-products (AGEs) and AOPPs share structural similarities and exert comparable biological effects

Storage and stability: Amber glass, refrigerated supply chain, and a slightly acidic pH (5 to 7) preserve the complex

10.1042/bj0291602 Biochem J