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Pattern recognition receptors in health and diseases

Circulating RNA represents extracellular transcripts released from tissues and immune cells into the bloodstream and has been increasingly used as a minimally invasive approach to assess nutrigenomic and inflammatory responses [88].FABP2 is a well-established circulating biomarker of intestinal epithelial integrity [89, 90], while occludin-related transcripts in serum are considered indirect indicators of tight-junction regulation and gut barrier modulation [89]