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Leading in the GLP-1 agonist diabetes arena are Eli Lillys recently approved Mounjaro (tirzepatide) and Novo Nordisks Ozempic (semaglutide), which has been a top seller for Novo since it first launched in 2017

Endocrinology 153(3):15381547 Mansoor H, L BA, Morten D, Kathleen D, G EF, R FD et al (2019a) Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

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Liraglutide exerts anti-catabolic effect in murine primary chondrocytes in vitro To explore the inhibitory effect of liraglutide on the production of catabolic mediators, IL-1-stimulated chondrocytes were cultured with 2 ng/mL of IL-1 and 10 ascending doses (6.6, 13.3, 26.6, 53.1, 106.3, 212.5, 425, 850 nM, 1.7 and 3.4 M) of liraglutide for 24 h for IC 50 determination

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Ces adaptations traduisent une meilleure oxygnation musculaire et un report de la fatigue