The sustained GH elevation from DAC can increase side effects including water retention and insulin resistance
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(b) Single small case series in knee pain A peer-reviewed article (Lee et al., Alternative Therapies in Health & Medicine , ~2021) describes: 12 patients with chronic knee pain Treated with intra-articular BPC-157, often combined with TB-500 7 of 12 reported symptom improvement lasting several months This study has major limitations: No control group No blinding No standardized outcomes (no KOOS, WOMAC, or imaging) Very small sample size Mixed interventions Conclusion: This study cannot demonstrate true benefit
Water Retention and Mild Bloating Increased GH and IGF-1 levels can cause transient fluid retention, particularly around joints or under the skin
Furthermore, the scientists reported that the treatment group had less postoperative fatigue and a lower risk of postoperative infection due to improved immune defenses
Nevertheless, brands must avoid claims implying wound healing, collagen regeneration, or medical efficacy