Initially, main concerns were receptor-activating activity while recently, downstream effects of GLP-1R and GIPR have been more and more revealed that not only receptor activation promotes cAMP and stimulates insulin releasing, but also other factors (-arrestin recruitment, residence time, etc.) influence receptor internalization, which further elicits long-term effects in vivo
Zhang YJ, Li S, Gan RY, Zhou T, Xu DP, Li HB
US-amerikanische Forscher haben 2013 in einer Tierstudie herausgefunden, dass sich bei einem erhhten Verzehr von rotem Fleisch Plaque bildet, der sich in den Herzgefen absetzt
The sequence has been used as a structural probe for the broader question of how short peptides cross cell membranes and engage gene-regulatory machinery
Turton MD, OShea D, Gunn I, Beak SA, Edwards CMB, Meeran K, et al
Kojic acid works externally by targeting pigmentation on the skin surface, while glutathione works internally by helping regulate melanin production and reducing oxidative stress, promoting long-term skin health
