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The resulting crude peptide is then cleaved from the resin, deprotected, and subjected to multistep purification (chromatography, crystallization) to remove byproducts, protecting groups, and residual solvent ( [20] )
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Over 250 medications are associated with OH [3], and the incidence of OH increases with advancing age [6]
This review synthesizes current knowledge on the liver-brain crosstalk in AD, emphasizing the mechanistic role of liver in bridging metabolic dysfunction with neurodegeneration and underscores the diagnostic and therapeutic potential of hepatokines in addressing ADs complex pathology
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