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And the dose-dependent effects were clear: 4 mg, 8 mg, and 12 mg doses all produced escalating weight loss, with the highest dose delivering the most dramatic results

2007 Dec;144(6):825-30

MD simulations showed that CME_bs binding mode changes in the first 200 ns, compared to the docking pose, CME preferentially interacted with the C1 region while chelating copper ions (Fig

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That is the entire mechanism