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High levels of IGF-1 can trigger the bodys negative feedback loop, potentially suppressing natural GH release over time

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In these embryos, PGCs switch from red fluorescence ( m embrane-targeted t dTomato, mT) to green fluorescence ( m embrane-targeted enhanced g reen fluorescent protein, mG) due to Blimp1-T2A-Cre expression 35 (Fig