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exenatide and lixisenatide, are based on a protein derived from saliva of the Gila monster, and only share roughly 50% of the homology of GLP-1, which could trigger immunogenicity
Notably, SR18 occupied the same orthosteric binding pocket on both conformers of GLP-1R, a binding site typically occupied by GLP-1 and other similar peptide mimetics, as evidenced in reported structural studies (Table 1
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Batool et al., 2020
This protocol is particularly suitable for people who are sensitive to semaglutide fatigue or gastrointestinal effects, and for those using semaglutide with B12 or semaglutide with glycine to mitigate side effects