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FIGURE 2 Role of NRF2 in neurodegenerative diseases Oxidative stress, neuroinflammation, and mitochondrial dysfunction are prevalent characteristics of the aging brain and research indicates that the expression of NRF2 and its downstream genes declines with age (Schmidlin et al., 2019)
It can be found in both oxidized and reduced forms
primary care-based study In a large nationally representative sample of U.S
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