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Disrupted sleep patterns alter gut motility and can worsen both diarrhea and constipation

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An extensive list of agents including thiazolidinediones, insulin-like growth factors, fibroblast growth factors, gastrin, glycogen synthase kinase-3 (GSK-3) inhibitors, protein kinase dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitors, gamma-aminobutyric acid, quinolones, sphingosine phosphate, oestrogens and phytoestrogens, polyphenols, flavonoids and other plant compounds has been reported to increase beta cell proliferation in vitro or in animal models, but specifically targeting these agents to pancreatic beta cells in vivo remains an unfulfilled therapeutic challenge [30]