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Freezing and thawing can degrade the peptide structure just as effectively as shaking it

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Hermes-Uliana C, Panizzon CPDNB, Trevizan AR, Sehaber CC, Ramalho FV, Martins HA, et al

10.1080/10520295.2017.1380842 Summary Keywords oxidative stress, male infertility, semen analysis, obesity, hypertension, diabetes mellitus Citation Ayad B, Omolaoye TS, Louw N, Ramsunder Y, Skosana BT, Oyeipo PI and Du Plessis SS (2022) Oxidative Stress and Male Infertility: Evidence From a Research Perspective

It almost always settles by week 2 at the current dose

1 If intolerable, providers should return to the last tolerable dosage or discontinue the drug