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Results Metformin alleviated OA pain in MIA-induced mouse model Firstly, an OA model was established by injecting MIA into the knee joints cavity of 6-month-old male C57 WT mice

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[7] Two trials in the phase 3 TRIUMPH program reached primary completion in April 2026: TRIUMPH-1, a master protocol in adults with obesity or overweight, and TRIUMPH-3, in participants with severe obesity and established cardiovascular disease

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