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Plan for behavioral and dietary changes in the months following discontinuation, since appetite typically returns to baseline

Follow a balanced diet with adequate protein intake to support muscle recovery and body composition

Most patients experience cycle normalization within 3-6 months as weight loss stabilizes and hormonal systems adapt

Contraindications Orlistat is contraindicated in patients with: Chronic malabsorption syndrome Cholestasis (blocked bile flow from the liver) Known hypersensitivity to orlistat or any component of the formulation Pregnancy and breastfeeding Monitoring and Duration of Use Treatment with orlistat should be discontinued after 12 weeks if a patient has not lost at least 5% of their initial body weight

Anemia makes the heart work too hard, leading to palpitations

N-Acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis