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In the liver, glutathione-S-transferases can attach glutathione to certain compounds, supporting their processing and elimination
On one hand, it directly quenches LOO to block the lipid peroxidation chain reaction in ferroptosis, and on the other hand, it inhibits NLRP3 inflammasome activation, reducing the release of inflammatory factors such as IL-6 and TNF-
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The absence of regulatory guidelines around dosage, frequency, and duration further complicates safety evaluations
Divergences from the consensus composition of an AR DNA-binding motif appeared to be associated also with the stage of CaP progression, as changes in ARE composition and location are seen both during prostate carcinogenesis and the development of ADT resistance
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