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They observed an attenuation of oxidative damage and early recovery of renal function in recipients who received NAC orally from day 0 to 7 postoperatively (123)

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Several mechanisms have been proposed to explain the cardiovascular protection, including: Blood pressure reduction : GLP-1 agents typically lower systolic blood pressure by 2-6 mmHg through natriuretic effects and improved endothelial function [5] Anti-inflammatory effects : Reduction in systemic inflammation markers including C-reactive protein and interleukin-6 Improved endothelial function : Enhanced nitric oxide availability and reduced oxidative stress Potential vascular effects : Emerging research suggests possible benefits on vascular function, though more human data are needed Additionally, GLP-1 medications have shown benefits in reducing albuminuria and slowing progression of diabetic kidney disease