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16,18 Early concerns about pancreatic safety arose from reports of pancreatitis in animal studies with the use of sitagliptin, clinical reports of humans treated with exenatide and the detection of preneoplastic pancreatic ductal lesions in animals treated with GLP-1 receptor agonists
& Rizvi, S
For randomized controlled trials, the Cochrane RoB 2.0 tool was applied across seven domains: random-sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome data, selective reporting, and other sources of bias
Currently, the 7 antiobesity medications (AOMs) approved by the FDA to treat obesity are phentermine, orlistat, phentermine/topiramate extended release (ER), naltrexone sustained release (SR)/bupropion SR, liraglutide (3.0 mg), semaglutide (2.4 mg), and tirzepatide
Our providers also offer alternatives, such as tirzepatide, for patients who are not good matches for semaglutide
Has WeightWatchers published research on GLP-1 outcomes
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