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Upon receptor binding, MT1 triggers the cAMP signaling cascade, upregulating the enzyme tyrosinase and increasing the production of eumelanin the dark, UV-protective form of melanin
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To get FDA approval for Zepbound , Eli Lilly had to prove the drug was safe, effective, and consistently manufactured through large-scale clinical trials (the SURMOUNT program)
Cite: Kim, D.S
(Teixeira et al., 2005)
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