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The rationale is elegant: because GLP-1 receptors are enriched in metabolically active brain regions, using GLP-1 as a delivery vehicle allows estrogen to be directed preferentially toward the central nervous system, potentially enhancing its neuroprotective effects while limiting systemic hormonal exposure

Beyond potential side effects, relying on unproven patches may delay access to treatments that are known to be effective and can actually improve long-term health

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8-15 lbs with diet/training