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Amino acids V12 (putative oxyanion hole), F112 (active site architecture), N108 (flavonoid binding) and C13 (GSH stabilization) were fully randomized by site saturation mutagenesis (NNK codons), and the created Pt GSTF8 variants were tested for conversion of flavan-3,3,4-triol ( 4 ) to cyanidin ( 8 ), and for their GSH-transferase activity towards CDNB ( 5 ) as a control of catalytic competence
For severe cystic acne,isotretinoin (Absorica, Accutane, Amnesteem, Claravis, Sotret, Zenatane) is the most effective therapy
The test phase was conducted on the following day, at the same time as the train phase
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doi: 10.1038/s41598-022-12086-8 99
Prefer topical glutathione serums or creams over high-dose intravenous (IV) glutathione in unregulated settings
