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doi:10.1161/CIRCULATIONAHA.105.552547

Human safety data is limited, so its full risk profile is not established

& McKenzie, M

PPAR controls the expression of a number of genes involved in adipocyte cell development and lipid and glucose metabolic pathways

5.5 Observational and Mechanistic Literature Mechanistic literature suggests several plausible pathways for nutritional vulnerability: Reduced food volume Reduced dietary fat affecting fat-soluble vitamin absorption Reduced red meat intake affecting iron and B12 intake Reduced whole-grain intake affecting magnesium intake However: Plausibility proven clinical depletion

Al-Jafari M, Alrosan S, Alkhawaldeh IM, Zein Eddin S, Abu-Jeyyab M, Zuaiter SN